Rubin 1987 book on multiple imputation schafer 1997 book on mcmc and multiple imputation for missingdata problems more subjectoriented carpenter, j. To obtain accurate results, ones imputation model must be congenial to appropriate for ones intended analysis model. Some of the most commonlyused software include r packages hmsic harrell 2011, function aregimpute, norm novo and schafer 2010, cat harding, tusell, and schafer 2011, mix schafer 2010 for a variety of techniques to create multiple imputations in continuous, categorical or mixture of continuous and categorical datasets. Multiple imputation by ordered monotone blocks with. Certainly, multiple imputation is an innovative approach over the traditional ones. There is a need to make available workable methodologies for handling missing data. There is currently only a limited amount of software for generating multiple imputations under multivariate completedata models and for analyzing multiplyimputed data sets i. One approach to incomplete data problems that potentially solves the above issues is multiple imputation rubin, 1987, schafer, 1997. Smallsample degrees of freedom for multicomponent signi.
These methods produce estimates that are superior to those of the older methods, but for many researchers, multiple imputation is the general solution to missingdata problems in statistics rubin, 1996. It presents a unified, bayesian approach to the analysis of incomplete multivariate data, covering datasets in which the variables are continuous, categorical, or both. In the imputed data, the observed incomes will still follow their empirical. For the imputation of a particular variable, the model should include variables in the completedata model, variables that are correlated with the imputed variable, and variables that are associated with the missingness of the imputed variable schafer 1997, p. The purpose of the paper is to propose a method that enables readers to write simple and e.
The following is the procedure for conducting the multiple imputation for missing data that was created by. M imputations completed datasets are generated under some chosen imputation. Although these instructions apply most directly to norm, most of the concepts apply to other mi programs as well. Automated procedures are widely available in standard software. A method of using multiple imputation in clinical data. A multipleimputation inference is obtained by applying a completedata inference procedure to each of the multiple data sets completed by imputation and then combining these estimates using simple combining rules. The last two decades have seen enormous developments in statistical methods for incomplete data.
The theoretical details of da are described in detail in schafer 1997, and its application to winlta is presented in hyatt, collins, and. Multiple imputation, which provides the basis for da, is a general approach to missing data problems that has been shown to produce high quality estimates and reliable standard errors schafer, 1997. It should be noted that this volume is not intended to be the exclusive source of the multiple imputation software. In multiple imputation, the parameters means and covariances of the joint distribution of observed and missing. To learn more about multiple imputation see rubin, 1987, 1996. Schafer 1997 developed various jm techniques for imputation under the multivariate normal, the loglinear, and the general location model. These methods include listwise deletion, pairwise deletion, mean substitution, regression imputation, maximumlikelihood methods and multiple imputation. State of the multiple imputation software europe pmc. Although the regression and mcmc methods assume multivariate normality, inferences based on multiple imputation can be robust to departures from the multivariate normality if the amount of missing information is not large schafer 1997, pp. When multiple imputation is better than maximum likelihood. Sep 16, 20 these methods produce estimates that are superior to those of the older methods, but for many researchers, multiple imputation is the general solution to missingdata problems in statistics rubin, 1996. Analysis of incomplete multivariate data helps bridge the gap between theory and practice, making these missingdata tools accessible to a broad audience. Multiple imputation for continuous and categorical data. Researchers frequently use ad hoc methods of imputation to obtain a complete data set.
Jul 28, 2017 in the literature, multiple imputation is known to be the standard method to handle missing data. Oct 01, 2010 multiple imputation is a popular way to handle missing data. The diversity of the contributions to this special volume provides an impression about the progress of the last decade in the software development in the multiple imputation. The idea of multiple imputation for missing data was first proposed by rubin 1977. It is said that da and fcs require betweenimputation iterations to be confidence proper schafer 1997. However, such automated procedures may hide many assumptions and possible difficulties from the view of the data analyst. Natasha beretvas university of florida the university of texas at austin the performance of multiple imputation mi for missing data in likerttype items assuming multivariate normality was assessed using simulation methods. Yet, in practical terms, those developments have had surprisingly little impact on the way most data analysts. Compares solas, sas, mice, splus implementations of imputation. The first part of a multiple imputation analysis is the imputation phase. Standalone windows software norm accompanying schafer 1997, operating. Multiple imputation is a popular method for addressing data that are presumed to be missing at random. Instead of lling in a single value for each missing value, a multiple imputation procedure replaces each missing value with a set of plausible values that represent the. Pdf statistical inference in missing data by mcmc and.
Avoiding bias due to perfect prediction in multiple. Multiple imputation mi is a popular way to handle missing data under the missing at random assumption mar little and rubin, 2002. Then, each of these completed datasets is analyzed using standard methods for complete data. We carry out multiple imputations using sas proc mi, which implements algorithms given by schafer, 1997. Multiple imputation by ordered monotone blocks with application to the anthrax vaccine research program fan li, michela baccini, fabrizia mealli, elizabeth r zell, constantine e frangakis, donald b rubin 1 abstract. The multiple imputation process using sas software imputation mechanisms the sas multiple imputation procedures assume that the missing data are missing at random mar, that is, the probability that an observation is missing may depend on the observed values but not the missing values. Multiple imputation using chained equations for missing. Multiple imputation can be used by researchers on many analytic levels. Multiple imputation for multivariate missingdata problems. New computational algorithms and software described in a recent book schafer, 1997 allow us to create proper multiple imputations in complex multivariate. Multivariate imputation by chained equations in r stef van buuren tno karin groothuisoudshoorn university of twente abstract the r package mice imputes incomplete multivariate data by chained equations. Multiple imputation mi has become a standard statistical technique for dealingwithmissingvalues. Using multiple imputation to address missing values of. Multiple imputation for missing data is an attractive method for handling missing data in multivariate analysis.
Abstract multiple imputation provides a useful strategy for dealing with data sets that have missing values. Inferences using the multiply imputed data thus account for the missing data and the uncertainty in the imputations. With multiple imputation, unobserved values are replaced by m 1 independent draws from an imputation model. Schafer 1997 provided a complete exposition of the method in the imputation setting, while gilks. Multiple imputation is a powerful and flexible technique for dealing with missing data. The em algorithm and its extensions, multiple imputation, and markov chain monte carlo provide a set of flexible and reliable tools from inference in large classes of missingdata problems. Assessing the effects of betweenimputation iterations. A simplified framework for using multiple imputation in. Because in multiple imputation, you only use the parametric model to impute missing incomes. The development of diagnostic techniques for multiple imputation, though, has been retarded by the belief that the assumptions of the procedure are untestable from observed data. Flexible, free software for multilevel multiple imputation. Multiple imputation an overview sciencedirect topics. New computational algorithms and software described in a recent book schafer, 1997 allow us to create proper multiple imputations in complex multivariate settings. Recent advances in analytic methods, such as multiple imputation mi, are taking hold in social work research.
The performance of multiple imputation for likerttype items. A variety of sources give additional details on multiple imputation allison, 2002, enders, 2010, rubin, 1987, rubin, 1996, schafer and olsen, 1998, schafer, 1997 and sinharay et al. Multiple imputation of missing values in a cancer mortality. Multiple imputation using chained equations for missing data. The multiple imputation procedure implemented in lisrel 8. In this chapter, i provide stepbystep instructions for performing multiple imputation with schafer s 1997 norm 2. The traditional multiple imputation method used by most commercial statistical software packages such as sas, iveware, etc. Four studies investigated specialized situations for multiple imputation, such as smallsample degrees of freedom in da barnard and rubin 1999, likertscale data in da leite and beretvas 2010, nonparametric multiple imputation cranmer and gill 20, and variance estimators hughes, sterne, and tilling 2016. Briefly, the missing data are stochastically imputed m times. Statistical inference in missing data by mcmc and nonmcmc multiple imputation algorithms. In the commonest approach, the m completed data sets are then analysed using methods appropriate for complete data, and the m results are combined using rubins rules rubin. An overview of the state of the art center for statistical research and methodology cs rm united states census bureau may16, 2015 views expressed are those of the author and not necessarily those of the u. In other words, the missing values are filled in m times to generate m complete data sets.
Multiple imputation for missing data statistics solutions. Reweighting, long used by survey methodologists, has been proposed for handling missing values in regression models with missing covariates ibrahim, 1990. Schafer 1997, van buuren and oudshoom 2000 and raghunathan et al. Multiple imputation using sas software yang yuan sas institute inc. Jun 10, 2010 new computational algorithms and software described in a recent book schafer, 1997a allow us to create proper multiple imputations in complex multivariate settings. While the theory of multiple imputation has been known for decades, the implementation is difficult due to the complicated nature of random draws from the posterior distribution. As an alternative to multiple imputation, parameter simulation can also be used to analyze the data for many incompletedata problems. Norm software program schafer, 1999, available free at.
Conceived by rubin and described further by little and rubin and schafer, multiple imputation imputes each missing value multiple times. Although the mi procedure does not offer parameter simulation, the tradeoffs between the two methods schafer 1997, pp. In recent years, multiple imputation has emerged as a convenient and flexible paradigm for analysing data with missing values. Ml and mi are now becoming standard because of implementations in free and commercial software. Missing data and multiple imputation columbia university. New computational algorithms and software described in a recent book schafer, 1997a allow us to create proper multiple imputations in complex multivariate settings. Adapted from schafer, jl 1997b, introduction to multiple imputations for missing data problems, viewed 6 may 2002. Imputation and multipleimputation procedures have been used in practice to handle the problem of ignorable nonresponse in. New computational algorithms and software described in a recent book schafer, 1997a allow us to create proper multiple imputations in. For generating imputations, software to implement the methodology developed by schafer 1997 has been written for the splus mathsoft, 2001 statistical. To be sure, often multiple imputation would also use an unrealistic parametric model for the joint distribution of incomes schafer 1997.
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